Robust presynaptic serotonin 5 - HT 1 B receptor inhibition of the striatonigral 3 output and its sensitization by chronic fluoxetine treatment 4 5 Running title : Fluoxetine sensitizes 5 - HT 1 B receptors
نویسندگان
چکیده
9 Department of Pharmacology, University of Tennessee College of Medicine 10 Memphis, TN 38163 11 12 13 Corresponding author: Fu-Ming Zhou, Department of Pharmacology, University of Tennessee 14 College of Medicine, Memphis, TN 38163 15 Phone: 901-448-1779, 16 Email: [email protected] 17 18 Abstract 202 words 19 Introduction 507 words 20 Discussion 1519 words 21 Number of pages 36 (including title page) 22 Figures 8 23 24 25 Acknowledgements: This work was supported by NIH grants R01NS058850 to FMZ. SD was 26 a recipient of University of Tennessee Neuroscience Institute FY2014 fellowship. The authors 27 thank Michèle Darmon and Hongbing Wang for advice on 5-HT1B receptor immunostaining. 28 29
منابع مشابه
Robust presynaptic serotonin 5-HT(1B) receptor inhibition of the striatonigral output and its sensitization by chronic fluoxetine treatment.
The striatonigral projection is a striatal output pathway critical to motor control, cognition, and emotion regulation. Its axon terminals in the substantia nigra pars reticulata (SNr) express a high level of serotonin (5-HT) type 1B receptors (5-HT(1B)Rs), whereas the SNr also receives an intense 5-HT innervation that expresses 5-HT transporters, providing an anatomic substrate for 5-HT and se...
متن کاملEffects of the antidepressant fluoxetine on the subcellular localization of 5-HT1A receptors and SERT.
Serotonin (5-HT) 5-HT(1A) autoreceptors (5-HT(1A)autoR) and the plasmalemmal 5-HT transporter (SERT) are key elements in the regulation of central 5-HT function and its responsiveness to antidepressant drugs. Previous immuno-electron microscopic studies in rats have demonstrated an internalization of 5-HT(1A)autoR upon acute administration of the selective agonist 8-OH-DPAT or the selective ser...
متن کاملLong-term treatment with fluoxetine induces desensitization of 5-HT4 receptor-dependent signalling and functionality in rat brain.
The mode of action of antidepressant drugs may be related to mechanisms of monoamines receptor adaptation, including serotonin 5-HT(4) receptor subtypes. Here we investigated the effects of repeated treatment with the selective serotonin reuptake inhibitor fluoxetine for 21 days (5 and 10 mg/kg, p.o., once daily) on the sensitivity of 5-HT(4) receptors by using receptor autoradiography, adenyla...
متن کاملReduced 5-HT1A- and GABAB receptor function in dorsal raphé neurons upon chronic fluoxetine treatment of socially stressed rats.
Autoinhibitory serotonin 1A receptors (5-HT(1A)) in dorsal raphé nucleus (DRN) have been implicated in chronic depression and in actions of selective serotonin reuptake inhibitors (SSRI). Due to experimental limitations, it was never studied at single-cell level whether changes in 5-HT(1A) receptor functionality occur in depression and during SSRI treatment. Here we address this question in a s...
متن کاملBoth exogenous 5-HT and endogenous 5-HT, released by fluoxetine, enhance distension evoked propulsion in guinea-pig ileum in vitro
The roles of 5-HT3 and 5-HT4 receptors in the modulation of intestinal propulsion by luminal application of 5-HT and augmentation of endogenous 5-HT effects were studied in segments of guinea-pig ileum in vitro. Persistent propulsive contractions evoked by saline distension were examined using a modified Trendelenburg method. When 5-HT (30 nM), fluoxetine (selective serotonin reuptake inhibitor...
متن کامل